The Renew.ORC project explores innovative technical solutions and investigates the possibility of using low GWP working fluids for ORC systems, studying their thermodynamic properties to maximise waste heat recovery from industrial processes. This research not only improves energy efficiency and reduces emissions, but also promotes a sustainable development model based on the circular economy. Collaboration between local companies and research centres stimulates technological growth and strengthens the industrial fabric, creating new economic opportunities. The project does not merely optimise a system, but introduces scalable solutions to make various production sectors more sustainable. By contributing to reducing the environmental impact of industry, it represents a concrete step towards energy transition and the fight against climate change.